Mexican Meatloaf with Salsa

A twist on an old favorite, our Mexican Meatloaf with Salsa is such a great way to eat dinner this week! Flavorful green chiles, melty cheese, and our signature taco seasoning combine with ground beef, cilantro and salsa for a meal you won’t want to miss! Make, bake, and go!

Our Mexican Meatloaf with Salsa on a white platter next to chopped tomatoes and avocados.

We are pretty much those people that have Taco- Tuesday every week. My kids requested we change it up, but still have the hispanic theme. (They love some chips and queso!) My husband requested something more filling, but with less carbs (no tortillas). This recipe is simple and packed with flavors and protein. Both the kiddos and hubby approved and we all LOVED changing up our Tuesday dinner plans!

Can I substitute a different kind of ground meat?

You can! In this particular recipe, we use a ground beef that is 80/20. That ratio of fat helps the meatloaf keep its shape as well as help the moisture. You can use a ground turkey, ground pork, or ground chicken. The taco seasoning is the predominant flavor in the meat, so the flavor shouldn’t change too drastically with a meat substitution.

Should I use a leaner meat than whats recommend?

You absolutely can, but we don’t recommend it! The fattier meat allows the meatloaf to keep its moisture and make the dish tender. If you use a lean meat, this can most often make the meatloaf tough and dried-out. If you opt for a leaner meat, we recommend covering with foil while baking and removing for the last 10 minutes.

Should I cover meatloaf when baking?

Whether or not you need to cover meatloaf when cooking will vary based on what recipe you use. For our recipe, you won’t need to. The meat we chose as well as the salsa layered on top keeps our meatloaf super moist and bakes evenly. If using a lean meat, we recommend covering to keep the meat from drying out.

The ingredients for the Mexican Meatloaf with Salsa on a red placemat.

Ingredients for our Mexican Meatloaf with Salsa:

  • Ground Beef
  • Can of Green Chiles
  • Shredded Cheese
  • Salsa
  • Taco Seasoning
  • Eggs
  • Optional Garnishes: ranch, lettuce, cilantro, avocado, tomatoes

How to make our Mexican Meatloaf with Salsa:

First, preheat oven to 375 F. In a large bowl, mix the ground beef, egg and taco spices together. I actually use my hands here because it makes it so easy!

A glass bowl with ground beef, two raw eggs, and taco seasoning.

Next, cut a large rectangular piece of waxed paper and lay it on a flat surface. Place the ground beef mixture on top of the paper and press into an even rectangle.

The meat mixture formed into a rectangle on top of wax paper.

Sprinkle with half of the cheese and the canned green chili peppers.

Ground beef mixture covered in green chiles and shredded cheese.

Slowly roll the waxed paper, with the meatloaf in the middle, until it shapes into a loaf. Place the loaf in a bread pan.

Ground beef mixture covered in green chiles and shredded cheese being rolled into a loaf.
Ground beef mixture covered in green chiles and shredded cheese rolled into a loaf.

Pour the salsa all over the top, evenly. Bake in oven at 375 for 50-55 minutes or until done. Sprinkle other half of cheese on top and bake additional 10 minutes, until the cheese and melted and bubbly.

Our meat loaf in a dish, covered in salsa, about to be cooked.

Serve and enjoy!

The final of our Mexican Meatloaf on a serving dish garnished with ranch, cilantro, avocados and diced tomatoes.

I’ve never been a huge fan of meatloaf…. until now! I especially love it topped with fresh avocado and drizzled in this Jalapeño Ranch! Everything comes together and tastes so delicious! Step Over Taco-Tuesday… Meatloaf Monday is coming your way!

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Mexican Meatloaf with Salsa
Yield: 10-12 Servings

Mexican Meatloaf with Salsa

Prep Time: 10 minutes
Cook Time: 55 minutes
Total Time: 1 hour 5 minutes


  • 2 pounds Ground Beef
  • 2 eggs
  • 1 (4oz) can of Green Chiles
  • 3/4 Cups Salsa
  • 2 cloves garlic, minced
  • 2 tablespoons Taco Seasoning
  • 2 cups of Cheese


    1. Preheat oven to 375 F.
    2. In a large bowl, mix the ground beef, eggs, garlic and taco seasoning together.
    3. On a piece of wax paper, place meat mixture in the middle and form a rectangle.
    4. Sprinkle with the can of green chiles and half of the cheese.
    5. Slowly roll the meat into a loaf (like pictured). Carefully lift and place in a loaf dish.
    6. Spread salsa evenly overtop and bake for 50 minutes.
    7. Remove from oven, sprinkle with the rest of the cheese and bake an additional 8-10 minutes, until cheese is melted.
    8. Remove and garnish with your favorites! We love: cilantro, ranch, avocado and diced tomatoes 🙂

Nutrition Information:



Serving Size:


Amount Per Serving: Calories: 312Total Fat: 21gSaturated Fat: 9gTrans Fat: 1gUnsaturated Fat: 9gCholesterol: 118mgSodium: 432mgCarbohydrates: 3gFiber: 1gSugar: 1gProtein: 27g

(Nutritional information provided is an estimate and will vary based on cooking methods and brands of ingredients used.)

Did you make this recipe?

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2 thoughts on “Mexican Meatloaf with Salsa”

  • I made this recipe last night. I don’t eat red meat so used ground turkey with 2 hot spiced chicken sausages. the rest was what you had in the recipe. It was really very good. Very easy to make…this will be now be made regularly .

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